极度早产儿童的神经行为症状:瑞典国家研究
Fredrik Serenius1,2, Ylva Fredriksson Kaul1, Karin Källén3
1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Acta paediatrica (Oslo, Norway : 1992)
|August 8, 2023
概括
极度早产 (EPT) 儿童的神经行为问题,包括注意力和社会困难的比例显著更高,与按期出生的同龄人相比. 这些问题甚至在没有智力障碍的EPT儿童中仍然存在,这突显了早期监测的必要性.
科学领域:
- 发育儿科 发育儿科
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 极度早产 (EPT) 出生 (怀孕27周以下) 对神经发育结果构成风险.
- 之前的研究表明,EPT幸存者的神经行为挑战,但在学龄的综合领域特定数据是有限的.
研究的目的:
- 为了确定在极度早产的儿童中在6.5岁时的神经行为症状的患病率.
- 为了比较EPT儿童和预产期对照之间的神经行为结果,包括没有神经发育障碍 (NDD) 的EPT儿童.
主要方法:
- 在瑞典 (2004-2007) 进行的一项基于人口的队列研究,包括375名EPT幸存者和369名匹配的满期出生对照.
- 父母问卷评估过度活动,注意力,情绪,同行关系,行为和社会问题,以及感知,语言和记忆缺陷.
- 分析了EPT儿童作为一个整体组,并单独对那些没有NDD的儿童进行分析.
主要成果:
- 与对照组相比,EPT儿童在所有评估领域中表现出神经行为问题的几率显著增加 (超过三倍).
- 在EPT儿童中,即使排除了神经发育障碍,也观察到神经行为问题的增加,除了行为问题.
- 经历≥3个同时出现的神经行为问题的可能性在整体EPT组是五倍高,在无NDDEPT组是三倍高.
结论:
- 极度早产的孩子,有或没有NDD,在多个领域中表现出神经行为问题的更高患病率,相比于他们出生时的同龄人.
- 早期识别和持续监测行为症状,包括注意力,社会,感知,情感和语言困难,对于EPT儿童至学龄及以后至关重要.
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