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与肥胖相关的高血压和慢性病:从评估到管理
Mi-Hyang Jung1,2, Sang-Hyun Ihm2,3
1Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kidney research and clinical practice
|August 8, 2023
概括
肥胖大流行将内脏脂肪与高血压和慢性病 (CKD) 的进展联系起来. 管理包括生活方式的改变,肥胖药物,减肥手术和密集的血压控制,以保护功能.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 全球肥胖流行病正在增加与肥胖相关的高血压率及其严重并发症,包括慢性病 (CKD).
- 肥胖引起的高血压是一个重要的风险因素,它在CKD的进展之前和加速.
- 了解肥胖,高血压和CKD之间的联系机制对于有效的临床管理至关重要.
研究的目的:
- 审查内脏脂肪在与肥胖相关的高血压病理生理学中的作用.
- 探索潜在的治疗策略,以预防和管理与肥胖相关的高血压及其对CKD的影响.
- 为了突出这一条件下生理系统的复杂相互作用.
主要方法:
- 关于肥胖相关高血压和CKD的病理生理学现有文献的综述.
- 分析了交感神经系统,- ангиотензин-阿尔多斯特系统和炎症通路的作用.
- 讨论临床影响和治疗干预措施.
主要成果:
- 内脏脂肪的积累通过涉及交感神经系统,氨酸-氨酸-阿尔多斯特系统和炎症的机制显著促进高血压.
- 与肥胖相关的高血压,通常对敏感或耐药,直接促进CKD的进展.
- 晚期CKD功能下降使血压管理复杂化,因为药物选择有限.
结论:
- 通过改变生活方式,药物治疗或减肥手术有效管理肥胖是必不可少的.
- 密集的血压控制对于预防和阻止肥胖个体中CKD的发展和进展至关重要.
- 针对肥胖和高血压的多方面的方法是必要的,以减轻CKD风险.
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