在新生儿中甲基马与甲的作用:一个比较性审查
Mehak Bhagat1, Purnima Singh2, Sindhu Meghana Sunkara3
1Internal Medicine, Government Medical College, Amritsar, IND.
Cureus
|August 8, 2023
概括
在妊娠中使用甲基和碳基来治疗甲状腺功能障碍与胎儿的结果比propylthiouracil更糟糕有关. 需要对propylthiouracil进行更多研究.
科学领域:
- 新生儿医学 新生儿医学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲状腺功能过高影响女性不成比例,甲状腺功能在怀孕期间发生改变.
- 增加的甲状腺激素和胺类药物可以显著影响母亲和胎儿的健康.
- 产前甲状腺功能障碍管理需要仔细考虑新生儿的药物安全性.
研究的目的:
- 审查有关甲基马和甲对新生儿的分析和临床影响的文献.
- 为了比较与美西马/卡比马与孕期使用甲的胎儿结局.
- 识别有关西奥拉新生儿效应的知识空白.
主要方法:
- 使用PubMed和谷歌学者进行了广泛的文献搜索.
- 确定并分析了10项相关研究.
- 数据提取和推断以确定药物特定的胎儿结果.
主要成果:
- 使用甲基马和炭基马的研究表明胎儿的不良结果,包括需要手术的先天性异常 (皮质无育症,胃).
- 甲的使用与较少的严重先天性异常有关,尽管有一例需要为诸如阴道囊等疾病进行手术.
- 在审查的研究中,甲基马和碳基马与甲相比,对胎儿的结果更差.
结论:
- 甲基马和碳基马似乎与治疗产前甲状腺功能障碍的孕产妇比propylthiouracil更严重的胎儿后果有关.
- 有一个显著的缺乏全面的数据,对长期影响的propylthiouracil在新生儿.
- 进一步的研究是必要的,以充分理解和减轻与这些抗甲状腺药物相关的新生儿风险.
关键词:
阿普拉西亚切割的情况.出生缺陷 产生的缺陷伤害胎儿的伤害严重的疾病 严重的疾病甲状腺功能过强症 甲状腺功能过强症甲基马索尔 (Methimazole) 是一种药物.甲甲甲甲甲甲甲甲甲甲甲它们具有原性地质.更多相关视频
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