自相关的基因会影响多发性骨髓瘤患者的生存,这取决于染色体异常
Gizem Ayna Duran1, Yasemin Benderli Cihan2
1Department of Biomedical Engineering, Faculty of Engineering, Izmir University of Economics, Balçova, İzmir 35330, Turkey.
Asian biomedicine : research, reviews and news
|August 8, 2023
概括
染色体异常显著影响多发性骨髓瘤 (MM) 患者的生存率. 根据这些异常,识别特定的自相关基因 (ARG) 可能为MM治疗提供新的治疗点.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
背景情况:
- 自在癌症的发展和治疗中起着重要作用.
- 染色体异常在多发性髓瘤 (MM) 中很常见.
- 自,染色体异常和MM预后之间的相互作用需要进一步调查.
研究的目的:
- 为了确定染色体异常对MM患者存活率的影响.
- 在MM患者中识别与预后相关的自相关基因 (ARG),按染色体异常状态分层.
主要方法:
- 利用了来自548名MM患者 (GSE24080) 的基因表达数据,并在1576名MM患者的单独队列中验证了1q21放大结果.
- 使用单变量和多变量考克斯回归和卡普兰-梅尔方法进行生存分析.
- 采用基因本体学 enRIchmentanaLysis和可视化 (GOrilla) 进行路径分析.
主要成果:
- 染色体异常显著影响了MM患者的整体存活率 (OS) 和无事件存活率 (EFS).
- 在患有染色体异常的患者中确定了41个对预后至关重要的ARG,在没有染色体异常的患者中确定了13个ARG.
- 发现CDKN1A,FKBP1B,FOXO3和NCKAP1在两组中都是常见的显著ARG,并且与生存结果相关.
结论:
- 基于染色体异常存在或不存在的MM患者的分层对预测生存至关重要.
- 在染色体异常患者中发现的与生存相关的ARG代表了MM治疗的潜在新型治疗点.
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