泰国儿童患有全身性红斑狼的骨矿物质密度低:流行率和危险因素

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Ankanee Chanakul¹, Suriyaphon Khunrattanaphon², Tawatchai Deekajorndech¹

¹Division of Nephrology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

Asian biomedicine : research, reviews and news

|August 8, 2023

概括

低骨质量在患有全身性红斑狼 (SLE) 的儿童中很常见,在诊断时影响了40%并且随着时间的推移而增加. 较高的皮质类固醇剂量可能与儿科SLE患者的这种并发症有关.

科学领域:

儿科风湿病学儿科风湿病学
骨的新陈代谢骨的新陈代谢
系统性红斑性狼红斑性狼系统性狼红斑性狼

背景情况:

儿童系统性红斑狼 (SLE) 的改善生存率将重点转移到长期并发症,如低骨质量和骨质疏松症.
成年SLE骨矿物质密度 (BMD) 低的危险因素包括年龄,炎症和皮质类固醇使用.

研究的目的:

确定泰国儿童诊断患有SLE的低骨矿物质密度 (BMD) 的患病率.
在这个儿科队列中确定与低BMD相关的危险因素.

主要方法:

对60名患有SLE的泰国儿童进行了回顾性审查.
双能X射线吸收计 (DXA) 在初次诊所和随访时进行.
低BMD定义为BMDz-score ≤ -2.0;用于风险因素分析的逻辑回归.

主要成果:

在初始诊断时,低BMD的患病率为40%,在随访期间增加到55%.
随着时间的推移,观察到部和腰部BMDz-score的显著下降.
较高的累积类固醇剂量显示出与低BMD相关的趋势 (OR=1.08,P=0.050).

结论:

低骨矿物质密度 (BMD) 在泰国儿童患有SLE的诊断时普遍存在,并且随着时间的推移而恶化.
累积的皮质类固醇剂量可能是危险因素,尽管在这个样本中没有统计学意义.
需要进一步的研究来确认风险因素,并制定针对儿科SLE低BMD的干预措施.

关键词:

在泰国,泰国语是泰国语.青少年发病的情况.红斑狼,全身性红斑狼骨质疏松症是一种骨质疏松症.类固醇类固醇是什么

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