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黑 (黑) 安全性:一个概述

Habibeh Mashayekhi-Sardoo¹, Ramin Rezaee^2,3, Gholamreza Karimi^1,4

¹Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad917794-8564, Iran.

Asian biomedicine : research, reviews and news

|August 8, 2023

概括

黑 (黑种子) 呈现出不同的毒性,取决于提取物和暴露时间. 虽然通常被认为是安全的,但需要进一步的研究来证实黑种子的整体安全性.

科学领域:

药理学药理学是指药理学的学科.
毒理学毒理学毒理学
植物化学植物化学

背景情况:

尼日利亚 (Nigella sativa) 或黑种子是一种具有长期药用历史的植物.
从N. sativa种子中提取的各种提取物和油被用于传统医学中.
了解N. sativa的毒理特征对于其安全应用至关重要.

研究的目的:

审查和综合现有关于尼日利亚三种子提取物和油的毒理学数据.
根据短期和长期研究来评估N. sativa的安全性.
为了确定与不同N. sativa制剂相关的潜在风险.

主要方法:

进行了对科学文献的叙事审查.
搜索的数据库包括科学网,PubMed,Scopus和谷歌学者.
分析了使用各种N. sativa提取物和油的研究中的毒理数据.

主要成果:

对于N. sativa固定油的LD50值差异很大 (在小鼠中为28.8毫升/公斤至3,371毫克/公斤).
高剂量的水性,甲醇和提取物 (21g/kg) 没有显示死亡率.
在6g/kg的低急性毒性研究中,这些提取物对这些提取物没有毒性.
慢性毒性表明N. sativa固定油2毫升/公斤的轻微毒性.
细胞毒性有所不同,和石油提取物更强效.

结论:

在大多数研究中,Nigella sativa通常被视为一种安全的药用草本.
然而,特定的提取物和剂量表现出不同的毒理作用.
需要进行更全面的研究,才能确定尼日利亚的安全性.

关键词:

4 - - 基门基因4 - - 基门基因阿尔法-海德林是一种卡尔瓦克罗尔 (Carvacrol) 是一种这种药物是thymoquinone.三烯酸盐的沙宁是一种三烯酸盐.

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