石替代对酸盐玻璃的功能活性的影响
Jeong-Hyun Ryu1, Utkarsh Mangal1, Myung-Jin Lee2
1Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Biomaterials science
|August 8, 2023
概括
用替代的基玻璃 (PSr) 通过刺激骨质活动和减少炎症来增强骨再生. 该PSr6成分显示出最佳的生物活性,并且在体内结果与生物活性玻璃相比较.
科学领域:
- 生物材料科学 生物材料科学
- 生物陶是生物陶中的一种.
- 材料化学 材料化学
背景情况:
- 酸盐基玻璃 (PBG) 是一种具有治疗性离子替代潜力的生物活性材料.
- 将 (Sr) 纳入PBG可能会增强骨质生和抗炎性质.
- 替代PBG (PSr) 中功能性活性最佳的Sr替代水平需要进一步的研究.
研究的目的:
- 合成和表征不同比例的替代PBG (PSr).
- 评估Sr替代对PSr.细胞生物反应和生物活性的影响.
- 为了比较最佳的PSr成分与45S5生物活性玻璃 (BG).
主要方法:
- 聚乙烯材料的合成和结构特征.
- 细胞活性的体外评估,骨质生性标志物表达 (ALP,骨质素) 和促炎性细胞因子抑制.
- 在体外矿化试验 (Alizarin Red S染色).
- 在子卡尔瓦里亚缺陷模型中的体内评估.
主要成果:
- 聚烯材料保留了玻璃结构和酸盐网络.
- PSr6表现出稳定的Sr和P释放,有利的细胞活力和强大的骨质生殖标记表达.
- 与BG相比,PSr6显著抑制了促炎性细胞因子.
- 在实验室中,PSr6表现出优异的骨质素和ALP表达以及增强的矿化.
- 在体内,PSr6的骨再生与BG的骨再生相似.
结论:
- PSr6代表了一种功能优化的成分,用于骨再生.
- PSr6表现出增强的生物活性,包括骨质刺激和抗炎作用.
- 在骨再生生物材料中,PSr6具有作为生物活性成分的潜力.
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