在动脉中与年龄相关的组织病理学发现
Ryan W Kendziora1, Joseph J Maleszewski1,2, Peter T Lin1
1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Histopathology
|August 8, 2023
概括
动脉 (TA) 与年龄相关的变化模仿治愈的巨细胞动脉炎 (GCA). TA组织学特征的综合得分 (CS) 随着年龄的增长而增加,可能有助于对老年人进行活检的正常化.
科学领域:
- 血管生物学 血管生物学
- 病理学 病理学 病理学
- 老年学是一门学科.
背景情况:
- 巨细胞动脉炎 (GCA) 是一种影响50岁以上个体中等至大动脉的血管炎.
- 动脉活检 (TAB) 是GCA诊断的黄金标准,但由于与年龄相关的动脉变化和并发症,解释是具有挑战性的.
- 在非GCA受试者中建立正常动脉 (TA) 组织学的基线对于准确的TAB解释至关重要.
研究的目的:
- 确定没有GCA的个体中动脉 (TA) 的基线组织学特征.
- 量化TA组织学中与年龄相关的变化.
- 开发一个评分系统,以区分正常衰老与TAB的GCA相关变化.
主要方法:
- 死后动脉 (TA) 样本从100名个人中收集.
- 标本被评估为亲密纤维形成,内部弹性层 (IEL) 破坏/化,以及中间衰减.
- 综合得分 (CS) 是通过总结内纤维形成,内线路干扰和中间衰减的得分来计算的.
主要成果:
- 组织学特征包括亲密增殖,IEL损失和IEL化随着年龄的增长显著增加.
- 综合得分 (CS) 显示出与年龄的统计学显著正相关性.
- 与年轻人相比,老年人群在TA组织学上表现出显著的差异.
结论:
- 正常的衰老会导致衰老的动脉变化,这些变化在组织学上类似于治愈的GCA.
- 开发的综合得分 (CS) 与年龄有显著的关联.
- CS可以作为一种工具来使老年患者的TA活检结果正常化,提高GCA的诊断准确性.
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