[多发性骨髓瘤与静脉血栓塞栓症复杂的危险因素]
Bing-Ni Zhao1, Chun-Xia Dong1, Jian-Min Kang1
1Department of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
Zhongguo shi yan xue ye xue za zhi
|August 8, 2023
概括
多发性骨髓瘤患者经常经历静脉血栓栓塞 (VTE). 过高的纤维素原 (FIB) 水平,高的D-二次体 (≥2000 ng/ml) 和IgG类型是这些患者静脉动脉突发症的关键危险因素.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 血栓形成的研究研究
背景情况:
- 多发性骨髓瘤 (MM) 与静脉血栓塞栓症 (VTE) 的风险增加有关.
- 在MM患者中确定VTE的特定风险因素对于预防和管理至关重要.
研究的目的:
- 在新诊断的多发性骨髓瘤 (NDMM) 患者中调查静脉瘤的临床特征.
- 确定与MM中VTE发展相关的独立风险因素.
主要方法:
- 分析了179名新诊断的MM患者的队列.
- 患者被分为VTE和对照组进行比较分析.
- 使用多变量逻辑回归来确定独立的风险因素.
主要成果:
- 与对照组相比,VTE患者表现出较低的血清白蛋白,较高的纤维素原 (FIB) 和较大比例的D-二元体≥2000 ng/ml.
- 在VTE组中,IgG M组件类型的患病率明显高.
- 多变量分析确定FIB升高,D-二次体≥2000 ng/ml和IgG类型作为独立的VTE风险因素.
结论:
- 多发性骨髓瘤患者具有对VTE的倾向.
- 纤维素水平,D-二元度和IgG类型是MM患者VTE的重要独立风险因素.
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