传播的BCG感染显示严重的综合免疫缺陷:一个病例报告
La Tunisie medicale
|August 8, 2023
概括
细菌卡尔梅特·盖林 (BCG) 疫苗可以在未被诊断的原发性免疫缺陷疾病的婴儿中引起致命的传播感染. 早期查对于预防高危新生儿BCG疫苗接种严重并发症至关重要.
科学领域:
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 针对突尼斯的新生儿,BCG疫苗接种是标准的.
- 在患有原发性免疫缺陷疾病 (PID) 的婴儿中,BCG可以引起严重的局部或扩散性疾病.
研究的目的:
- 报告在患有严重综合免疫缺陷疾病 (SCID) 的婴儿中传播BCG感染的致命病例.
- 强调BCG疫苗接种在未诊断的PID患者中的风险.
主要方法:
- 一个3个月大的男孩的病例报告,患有持续的发烧,肝壮症和骨解损伤.
- 诊断SCID和传播的BCG感染.
- 用抗结核疗法和静脉注射免疫球蛋白进行治疗.
主要成果:
- 婴儿出现了与传播BCG感染一致的症状.
- 尽管接受了治疗,但婴儿的病情是致命的.
- 该案例说明了BCG疫苗接种的罕见但致命的并发症.
结论:
- 在未被诊断为PID的婴儿中,BCG疫苗接种具有显著的风险.
- 建议在BCG接种之前对PID进行查,以防止严重的结果.
- 推迟BCG疫苗接种,直到PID被排除在外,可以挽救生命.
更多相关视频
11:17A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
Published on: August 11, 2018
12.1K
07:14A CFSE-based Assay to Study the Migration of Murine Skin Dendritic Cells into Draining Lymph Nodes During Infection with Mycobacterium bovis Bacille Calmette-Guérin
Published on: October 9, 2016
12.2K
相关概念视频
Immunodeficiency Diseases
974
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
974
Pulmonary Tuberculosis I
268
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
268
Pulmonary Tuberculosis IV
162
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
162
Pulmonary Tuberculosis II
263
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
263
Pulmonary Tuberculosis III
365
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
365
