相关实验视频
Updated: Jul 19, 2025

03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
485
从基因组规模的癌症查中对基因列表的全面查询使用oncoEnrichR
Sigve Nakken1,2,3, Sveinung Gundersen3, Fabian L M Bernal4
1Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
International journal of cancer
|August 8, 2023
概括
oncoEnrichR通过整合各种癌症特定数据,简化了癌症基因列表分析. 这种生物信息学工具有助于研究人员优先考虑候选基因进行进一步研究,并有效地获得生物见解.
科学领域:
- 生物信息学是一种生物信息学.
- 癌症研究 癌症研究
- 基因组学就是基因组学.
背景情况:
- 在癌症中基因组规模查产生了广泛的基因列表,需要复杂的解释.
- 实验生物学家目前使用多个生物信息学资源,这是一个耗时的过程.
- 为癌症研究优先考虑候选基因对于生物学洞察力和后续研究至关重要.
研究的目的:
- 开发一个灵活的生物信息学工具,oncoEnrichR,用于全面的癌症基因列表查询.
- 简化和加强对基因列表的癌症相关性分析过程.
- 为研究人员提供结构化和用户友好的分析报告.
主要方法:
- 在coEnrichR上开发,整合了癌症特定的先前知识.
- 包括基因与瘤类型的关联,原瘤基因,瘤抑制剂,药物可用性,调控相互作用,合成致死性,预后关联,基因异常和共同表达模式的数据.
- 确保了基础数据资源版本的显式记录,以确保可重复性.
主要成果:
- oncoEnrichR允许在多个癌症相关方面对基因列表进行查询.
- 该工具整合了一套独特的癌症特定知识库.
- 通过蛋白质组和CRISPR屏幕的候选清单证明了它的有用性.
结论:
- oncoEnrichR为癌症基因列表分析提供了一种简化方法.
- 该工具增强了癌症研究的生物洞察力和优先级.
- oncoEnrichR可以作为Web服务和R包进行访问,以实现广泛的可用性.
相关概念视频
Cancer-Critical Genes I: Proto-oncogenes
9.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.0K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.5K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.5K
Cancer Survival Analysis
384
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
384
Genomics
36.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.5K
DNA Microarrays
17.5K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
17.5K

