杰出的吉尔卵细胞捐赠者:个体因素如何影响体外胚胎生产效率?
Clara Slade Oliveira1, Paola Maria da Silva Rosa1, Agostinho Jorge Dos Reis Camargo2
1Embrapa Dairy Cattle, Juiz de Fora, Minas Gerais, Brazil.
Animal science journal = Nihon chikusan Gakkaiho
|August 8, 2023
概括
选择高效的卵细胞捐赠者可以显著提高牛体内胚胎生产 (IVP) 的成功率. 专注于具有高胚胎细胞/卵细胞比率的捐赠者可以增加胚胎和怀孕率,改善IVP计划的结果.
科学领域:
- 生殖生物学 生殖生物学
- 动物科学动物科学
- 胚胎学 胚胎学
背景情况:
- 卵细胞供体的变异性是影响牛体内胚胎生产 (IVP) 成功率的关键因素.
- 识别高性能动物对于优化IVP效率和牛的生殖结果至关重要.
研究的目的:
- 量化个体卵细胞捐赠者的表现对吉尔牛群体内IVP效率的影响.
- 评估通过胚胎囊/卵细胞比衡量的供体效率与关键IVP指标之间的关系.
主要方法:
- 分析了来自250名吉尔卵细胞捐赠者的1,734个观察结果,根据胚胎细胞/卵细胞比率分为高 (>0.48),平均 (0.17-0.48) 和低 (<0.17) 效率组.
- 在捐赠者效率组中,对累积卵细胞复合体指标和胚胎生产率 (每OPU的胚胎囊,每OPU的怀孕) 的比较.
主要成果:
- 与平均和低效率组相比,高效率的捐赠者表现出较低的累积卵细胞复合指标 (总数,试管婴儿等级数,试管婴儿等级/总比率) (p < 0.05).
- 每个OPU的胚胎细胞产量在高效率的捐赠者中显著更高,在低效率的捐赠者中较低,而不是平均组 (p < 0.05).
- 与低效率捐赠者相比,高效率捐赠者每OPU的怀孕率是高效率捐赠者的4.3倍 (p = 0.017).
结论:
- 基于高胚胎囊/卵细胞比例的供体选择是提高牛IVP胚胎囊和怀孕产量的关键策略.
- 利用高效率的捐赠者显著提高了在畜牧业IVP计划的整体成功和经济可行性.
相关概念视频
01:24In Vitro Fertilization
329
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
329
02:07Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K