在经过口腔机器人手术后,口腔癌患者的急性味觉功能障碍
Theresa Tharakan1, Jay F Piccirillo1, Brevin Miller1,2
1Department of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA.
The Laryngoscope
|August 8, 2023
概括
透口机器人手术 (TORS) 经常导致口腔癌患者的口味变化. 与对照组相比,TORS患者的味觉识别能力下降,暂停时间和神经损伤是不太可能的原因.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 手术瘤学手术瘤学
- 味觉科学 味觉科学
背景情况:
- 口腔癌的治疗可以显著影响患者的生活质量.
- 味觉功能障碍是头癌治疗后的一个常见问题.
- 透口机器人手术 (TORS) 提供了一种最少的侵入性方法,但它对味道的影响需要详细的研究.
研究的目的:
- 为了比较经过TORS的口腔癌患者的口味变化与健康对照组的口味变化.
- 评估TORS对口味识别,强度和享乐学的影响.
- 评估手术因素 (悬置时间,神经损伤) 和味觉变化之间的关系.
主要方法:
- 一项非随机对照队列研究,涉及69名参与者 (37名TORS患者,32名对照).
- 在基线和2周的随访期间进行了心理味道测试 (识别,强度,享乐学).
- 外科医生报告了暂停时间和光喉神经损伤 (GNI);用临床全球印象 (CGI) 尺度评估了味觉症状.
主要成果:
- 42%的TORS患者出现了新的味觉障碍 (TD),而对照组没有.
- TORS患者的瘤-ipsilateral味道识别显著下降 (-11.3%) 与对照组 (0.8%) 相比.
- 吸烟者和没有GNI的患者报告了更多的味道障碍;悬浮时间与味道变化无关.
结论:
- 患者报告的味道变化在TORS治疗口腔癌后很常见.
- 与健康个体相比,TORS与瘤-ipsilateral侧减少的味道识别有关.
- 需要进一步的研究,以了解TORS相关的味觉功能障碍的病因和长期影响,以改善患者管理.
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