眼近视和玻璃眼如何影响视神经头部的生物机械敏感性
Thanadet Chuangsuwanich1,2, Tin A Tun3,4, Fabian A Braeu2,4
1Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Investigative ophthalmology & visual science
|August 8, 2023
概括
高度近视的眼睛比病态近视的眼睛更少地显示视神经头部 (ONH) 变形. 病态近视与稳形瘤眼睛在升高的眼内压力 (IOP) 下显示出最高的ONH菌株.
科学领域:
- 眼科医生 眼科 眼科
- 生物力学 生物力学
- 医疗成像医学成像
背景情况:
- 视神经头部 (ONH) 变形在近视和绿眼中至关重要.
- 了解压力下的ONH生物力学对于评估疾病进展至关重要.
研究的目的:
- 为了评估ONH变形响应急性眼内压力 (IOP) 升高和眼睛运动.
- 为了将这些变形在对照中进行比较,高度近视 (HM),高近视与绿眼 (HMG) 以及病态近视 (PM) 的眼睛,包括那些患有稳形瘤 (PM + S) 的眼睛.
主要方法:
- 用光谱域光学连贯性断层扫描 (OCT) 来绘制不同组282只眼睛的ONH图像.
- 眼睛在初级凝视下成像,水平眼动 (吸附/绑架) 和急性内血压升高 (至~35毫米升).
- 计算和比较了IOP和目光诱导的ONH位移和有效菌株.
主要成果:
- 在升高的内血压下,HM眼睛与PM (6.9%),HMG (4.7%) 和PM + S (7.0%) 眼睛相比显示出明显较低的菌株 (3.9%).
- 与PM + S眼睛 (6.0%) 相比,HM眼睛在引过程中表现出较低的菌株 (4.8%).
- 较高的轴长与增加的ONH菌株相关.
结论:
- 与HMG眼相比,具有HMG的眼睛在IOP下显示出更多的ONH菌株.
- 患有PM+S的眼睛在所有研究组中表现出最高的ONH菌株.
- 轴长是影响ONH菌株的一个重要因素.
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