急性至慢性肝衰竭的重症监护管理
Giovanni Perricone1, Thierry Artzner2, Eleonora De Martin3
1Hepatology and Gastroenterology Unit, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3, 20162, Milan, Italy. giovanni.perricone@ospedaleniguarda.it.
Intensive care medicine
|August 8, 2023
概括
急性至慢性肝衰竭 (ACLF) 是一种具有高死亡率的严重肝病,其特征是器官衰竭和全身炎症. 重症监护室管理和肝移植是改善患者治疗结果的关键.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 关键护理医学 关键护理医学
- 免疫学 免疫学 免疫学
背景情况:
- 急性至慢性肝衰竭 (ACLF) 是肝硬化患者死亡的重要原因.
- ACLF的特点是急性肝脏衰竭和肝外器官衰竭,需要密集护理.
- 系统性炎症是ACLF的中心病理生理机制,为新型疗法提供了点.
研究的目的:
- 提供当前对ACLF的理解的概述.
- 强调对ACLF患者的重症监护管理策略.
- 讨论肝移植在ACLF治疗中的作用.
主要方法:
- 这篇叙事综述综合了ACLF的当前知识.
- 它侧重于重症监护病房 (ICU) 管理原则.
- 它检查了包括肝移植在内的治疗选择.
主要成果:
- 在ICU中的ACLF管理需要定制的策略,而不是一般的重症监护.
- 在决定重症监护干预和肝移植时,徒劳性考虑至关重要.
- 肝移植仍然是ACLF的唯一确定的治愈治疗方法,显著改善了长期生存率.
结论:
- 有效管理ACLF涉及专业的ICU护理和仔细考虑预后.
- 肝移植为符合条件的ACLF患者提供了长期生存的最佳机会.
- 正在进行的针对系统性炎症的新疗法的研究是有希望的.
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