通过对比增强型计算机断层扫描实时跟踪现场形成的酸盐水凝
Natalie Guirguis1, Yanis Zellagui1,2, Simon Matoori3
1Faculté de Pharmacie, Université de Montréal, 2940 Chemin de Polytechnique, Montreal, Québec, H3T 1J4, Canada.
The AAPS journal
|August 8, 2023
概括
研究人员开发了一种新方法,使用计算机断层扫描 (CT) 和X射线使酸盐水凝可见. 这项创新允许实时跟踪体内的水凝,这对于组织工程和药物输送至关重要.
科学领域:
- 生物材料科学 生物材料科学
- 医疗成像医学成像
- 组织工程是组织工程.
背景情况:
- 基于水凝的生物材料广泛用于组织工程和药物输送.
- 精确定位水凝对于防止迁移和确保治疗疗效至关重要.
- 由于它们的高含水量,成像水凝具有挑战性.
研究的目的:
- 开发一种方法,使用CT和X射线实时跟踪人体内的酸盐水凝.
- 为了研究使用ethiodized油作为对比剂用于水凝成像.
主要方法:
- 用微米大小的水滴制备一种油在水中乳液的ethiodized油.
- 在与交联的酸盐水凝中封装乳液.
- 在小鼠体内稳定性测试和体内成像 (CT和X射线).
主要成果:
- 开发的水凝是可注射的,并且在现场形成.
- 在体外,水凝在至少两周内表现出稳定性.
- 在小鼠中使用CT和X射线成功可视化了水凝,信号强度与对比剂度相关.
- 获取的水凝保持了适当的风学特性 (储存模量~2kPa,损失模量~0.35kPa).
结论:
- 化油可以有效地固定在酸盐水凝中,使其在CT和X射线上可见.
- 这种方法可以实时定位和跟踪体内的水凝.
- 这种方法为FDA批准的对比剂在生物材料成像中提供了新的应用.
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