在ROR2/CREB信号通路的下游,ASCL1被激活,以支持前列腺癌的血统可塑性

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Updated: Jul 19, 2025

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
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Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

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Nakisa Tabrizian1, Shaghayegh Nouruzi1, Cassandra Jingjing Cui1

  • 1Department of Urologic Sciences, The University of British Columbia, Vancouver, BC V5Z 1M9, Canada; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada.

Cell reports
|August 8, 2023
PubMed
概括

雄激素受体 (AR) 途径抑制剂可以通过血统可塑性引起前列腺癌复发. 研究人员发现,ROR2激活通过促进干细胞类网络来驱动这种抵抗,这表明ROR2是治疗点.

关键词:
在ASCL1中,CP: 癌症 癌症 癌症克里布 (Creb) 是一个非常重要的数字.在ROR2中使用ROR2.细胞的可塑性 细胞的可塑性神经内分泌神经内分泌前列腺癌是前列腺癌.

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