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Updated: Jul 19, 2025

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
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由抗病毒治疗驱动的致命突变发生的进化安全性

Gabriela Lobinska1, Yitzhak Pilpel1, Martin A Nowak2

  • 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

PLoS biology
|August 8, 2023
PubMed
概括

像Molnupiravir这样的突变性抗病毒药物可能会引发进化的安全问题. 数学建模表明,Molnupiravir几乎是安全的,但优化治疗和药物设计可以提高病毒进化安全性.

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