使用基因组序列数据推断侵入的方向
Yuttapong Thawornwattana1, Jun Huang2, Tomáš Flouri3
1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Molecular biology and evolution
|August 8, 2023
概括
使用基因组数据推断基因流动的方向具有挑战性. 新的方法表明,更容易检测基因流动从较小到较大的群体和从外组到内组.
科学领域:
- 进化生物学 进化生物学
- 基因组学就是基因组学.
- 人口遗传学 人口遗传学
背景情况:
- 基因组数据揭示了物种分歧和基因流动历史.
- 推断基因流动的方向是很困难的,因为双向基因流动的类似模式.
研究的目的:
- 调查基因组序列数据中的信息,以推断基因流动方向.
- 根据多物种-同青春期与入侵模式,开发和应用基于概率的方法.
主要方法:
- 采用基于概率的方法和多种类共生与入侵模型.
- 分析了两种物种的基因组序列,并对三种或四种物种进行模拟.
- 应用方法从Heliconius蝶的基因组数据.
主要成果:
- 推断基因流更容易从小到大种群,从外组到内组.
- 基因流检测在较长的分离进化时间下更成功.
- 错误推断的内进方向可以导致准确的时间估计和显著的贝叶斯测试.
结论:
- 基因组数据集有助于确定跨种基因流动的方向,时间和强度.
- 开发的方法提高了我们重建复杂进化历史的能力.
相关概念视频
Evolutionary Relationships through Genome Comparisons
5.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.8K
Gene Evolution - Fast or Slow?
7.2K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
7.2K
Genetics of Speciation
19.3K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
19.3K
Gene Flow
35.2K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
35.2K
Gene Duplication and Divergence
6.2K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
6.2K
Horizontal Gene Transfer
40
Horizontal gene transfer (HGT) is a process where genetic material moves between organisms within the same generation, unlike vertical gene transfer, which occurs from parent to offspring. HGT plays a crucial role in microbial evolution, adaptation, and survival, particularly in shared environments like the human gut.Mobile genetic elements such as plasmids, prophages, integrons, insertion sequences, and transposons facilitate this process. HGT occurs through three primary mechanisms:...
40


