2型糖尿病和片使用事件之间的关联:身体质量和肥胖的调解
American journal of epidemiology
|August 8, 2023
概括
长期使用片与患2型糖尿病 (T2DM) 的风险降低有关. 这种保护作用主要由较低的体重指数 (BMI) 和减少阿片使用者的脂肪度介导.
科学领域:
- 代谢健康 代谢健康
- 流行病学 流行病学
- 药物使用研究研究 药物使用研究
背景情况:
- 众所周知,阿片类药物会影响葡萄糖代谢和肥胖.
- 关于片使用对体重指数 (BMI) 和2型糖尿病 (T2DM) 发病率的长期影响的有限的大规模前性研究存在.
研究的目的:
- 调查长期片使用,BMI和事件T2DM在一个大前景队列中的关联.
- 评估BMI在片使用与T2DM发病率之间的关系中的调解作用.
主要方法:
- 分析伊朗戈勒斯坦队列研究 (n=40,083) 的前性数据.
- 用调整的波桑回归模型来估计发病率比率 (IRR) 和置信区间 (CI).
- 用调解分析来评估BMI调解的关联.
主要成果:
- 片使用与T2DM发病率降低有关 (IRR=0.83,95% CI:0.75,0.92),显示了剂量反应关系.
- 这种关联的大多数 (84.3%) 是通过较低的BMI和腰围来调解的.
- 片使用与发生的T2DM没有直接关联 (IRR=0.97,95%CI:0.87,1.08).
结论:
- 长期使用片与2型糖尿病发病率较低有关.
- 这种关联主要通过减少体质和脂肪度来调解,而不是对T2DM发展产生直接影响.
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