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Control of Eating Behavior Using a Novel Feedback System
Published on: May 8, 2018
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与情绪障碍相关的神经过敏的食欲调节中的前时功能障碍:区域同质性和远程连接模式分析
Jiani Wang1, Lirong Tang2, Miao Wang3
1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Journal of affective disorders
|August 8, 2023
概括
脑部成像显示,在神经过食症 (BN) 和情感障碍患者中,前额连接发生了变化. 这些功能变化与不适应的饮食行为有关,为这种疾病的神经支提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 神经过敏 (BN) 经常伴随着焦虑和抑郁等情感障碍.
- 了解BN背后的神经机制,特别是在并发性情绪障碍的背景下,对于开发有效的治疗方法至关重要.
研究的目的:
- 调查BN患者和同时发生的情绪障碍患者的大脑功能变化.
- 探索这些大脑功能变化与BN患者的不适应性饮食行为之间的联系.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 用于分析区域同质性 (ReHo) 和功能连接性 (FC).
- 42名患有情感障碍的BN患者和47名健康对照 (HC) 参与了这项研究.
- 主要组件分析 (PCA) 用于识别行为数据中的模式.
主要成果:
- 在BN患者中,双边中额头 (MFG) 和右上边 (SMG) 中的ReHo降低.
- 观察到功能连接的改变,包括左侧MFG和右侧下椎间盘 (ITG) 之间的FC增加,以及涉及MFG,insula,中椎间盘 (MTG),SMG,上椎间盘 (STG) 和下椎间盘 (IFG) 的FC减少.
- 在代表行为模式的主要组成部分和左侧MFG和右侧ITG之间的FC之间发现了负相关性.
结论:
- 在患有情感障碍的BN患者中,在前额部区域发现了显著的异常功能变化.
- 这些改变的前时回路与情绪调节和饮食行为有关.
- 这些发现为BN的神经生物学基础及其与情绪障碍和饮食模式的关联提供了新的见解.
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