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在体内偏振敏感的光学连贯断层扫描,用于评估间歇性肺部疾病中的纤维化:一个前性,探索性,观察性研究

Margherita Vaselli¹, Kirsten Kalverda-Mooij², Erik Thunnissen³

¹Department of Physics and Astronomy, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands m.vaselli@vu.nl.

BMJ open respiratory research

|August 8, 2023

概括

对于检测肺纤维化而言,内支柱极化敏感光学连贯性断层扫描 (EB-PS-OCT) 的分辨率比HRCT高出50倍. 这种技术在间歇性肺病 (ILD) 患者中准确量化纤维化,性能优于HRCT.

科学领域:

肺部医学肺部医学
医疗成像医学成像
病理学病理学病理学

背景情况:

高分辨率CT (HRCT) 在可视化和量化肺纤维化方面存在局限性.
胸膜极化敏感光学连贯性断层扫描 (EB-PS-OCT) 是一种新的支气管镜成像技术,其分辨率明显高于HRCT.
EB-PS-OCT检测到原双断层,这是纤维化的一个关键指标.

研究的目的:

评估EB-PS-OCT在体内评估肺纤维化在间歇性肺部疾病 (ILD) 患者的疗效.
使用组织学作为验证EB-PS-OCT发现的参考标准.
为了比较EB-PS-OCT与HRCT在检测和量化肺纤维化方面的诊断性能.

主要方法:

进行了一项观察性前性探索性研究.
患有ILD的患者在经支气管或手术肺活检之前接受了体内EB-PS-OCT成像.
喘患者作为非纤维化的对照;纤维化被量化为EB-PS-OCT图像中的双断层区域,并与HRCT和组织学相比较.

主要成果:

包括19名患者 (16名ILD,3名喘患者),对49个气道段进行了成像.
EB-PS-OCT成功量化了对酶体双断层区域,与纤维化程度相关 (2.54%至21.01%).
经EB-PS-OCT证明了纤维化比HRCT更好的预测值,并确定了微观ILD特征.

结论:

通过EB-PS-OCT,可以准确量化肺纤维化.
这种技术有可能成为诊断和检测ILD早期纤维化的辅助支气管镜工具.
EB-PS-OCT可视化了微观ILD特征,有助于诊断.

关键词:

支气管镜检查 (bronchoscopy) 是一种支气管镜检查.图像/CT MRI 等等,这些都需要检查.间歇性纤维化间歇性纤维化

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