膜相位过渡产生了响应性等离子体膜结构和功能
Sarah A Shelby1, Sarah L Veatch2
1Biochemistry & Cellular and Molecular Biology, University of Tennessee Knoxville, Knoxville, Tennessee 37996, USA sshelby4@utk.edu sveatch@umich.edu.
Cold Spring Harbor perspectives in biology
|August 8, 2023
概括
细胞膜通过组织蛋白质形成动态域. 这种膜相位分离是由它们与相位过渡的接近驱动的,使细胞功能能够响应.
科学领域:
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
- 膜生物物理学 膜生物物理学
背景情况:
- 最近的研究表明,血膜域通过蛋白质组织形成.
- 这些域招募液体排序相位元件,连接到膜相位分离.
- 几十年的研究探索了膜相分离在细胞组织中的作用.
研究的目的:
- 提出一个热力学模型,用于等离子体膜领域的形成.
- 解释膜组成如何影响域的出现和稳定性.
- 将膜组成的景观与细胞生物化学和功能联系起来.
主要方法:
- 膜混合性的热力学建模.
- 分析相位过渡附近的组成易感性.
- 将现有的实验观测纳入拟议模型.
主要成果:
- 接近混合性相位过渡的膜表现出高的组成易感性.
- 这种易感性允许短暂的组成波动和稳定的诱导域.
- 膜组成的生物调整创造了一个响应的景观.
结论:
- 一个热力学框架解释了等离子体膜域的形成和动态.
- 膜相位行为对于组织细胞生物化学是至关重要的.
- 这个模型统一了过去和现在关于膜组织的观察.
更多相关视频
08:55Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence TIRF Microscopy
Published on: February 17, 2023
3.2K
07:31Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
Published on: September 1, 2023
2.3K
相关概念视频
Membrane Fluidity
152.9K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
152.9K
Fluid Mosaic Model
12.0K
Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
12.0K
The Fluid Mosaic Model
149.0K
The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.
149.0K
Asymmetric Lipid Bilayer
7.3K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
7.3K
What are Membranes?
13.4K
A cell's plasma membrane demarcates the cell's borders and determines the nature of its interaction with the environment. Cells exclude certain substances, take in others, and excrete some others in controlled quantities. The plasma membrane must be flexible to allow certain cells, such as red and white blood cells, to change their shape while passing through narrow capillaries. These are the more obvious plasma membrane functions. In addition, the plasma membrane's surface carries...
13.4K
Enlargement of the Plasma Membrane
1.9K
Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...
1.9K
