肝脂肪作为肝脏和心脏代谢疾病的危险因素
Münevver Demir1, Stefan R Bornstein2,3,4,5, Christos S Mantzoros6
1Department of Hepatology and Gastroenterology, Campus Virchow Clinic and Campus Charité Mitte, Charité University Medicine, Berlin, Germany.
概括
过多的肝脂肪,非酒精性脂肪性肝病 (NAFLD) 的标志,独立预测疾病进展和代谢并发症. 减少肝脏脂肪是管理NAFLD和相关疾病的关键.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 临床研究 临床研究
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 涉及过度的肝脏脂肪积累.
- NAFLD可以发展为非酒精性脂肪肝炎 (NASH),纤维化和肝硬化.
- 肝脂肪是NAFLD和代谢性疾病进展的独立风险因素.
研究的目的:
- 审查目前用于量化人类肝脏脂肪的方法.
- 检查肝脂肪与NAFLD/心脏代谢疾病进展之间的联系.
- 讨论目前和未来减少肝脏脂肪的策略.
主要方法:
- 对用于量化肝脂肪的诊断工具的文献综述.
- 分析临床和病理生理学证据,将肝脂肪与疾病联系起来.
- 综合有关药理和非药理干预的数据.
主要成果:
- 肝脏脂肪量化工具可用于临床使用.
- 强有力的证据将肝脏脂肪积累与NAFLD进展和心脏代谢风险联系在一起.
- 有各种方法可以减少肝脏脂肪,目前仍在进行研究.
结论:
- 肝脏脂肪是NAFLD和代谢性疾病发病的一个关键因素.
- 针对肝脏脂肪的减少是一个有前途的治疗策略.
- 需要进一步的研究来解决NAFLD管理中的悬而未决的问题.
相关概念视频
Overview of Lipid Metabolism
1.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.8K
Cholesterol: Significance and Regulation
584
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
584
Diseases of the Liver and Gallbladder
631
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
631
Liver Physiology
635
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
635
Lipids: Dietary Sources and Requirements
838
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
838
Blood Studies for Cardiovascular System III: Serum Lipid Profile
194
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
194


