在口腔平的血管生成的异国病原学机制 - 一个系统的审查

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R Keerthika¹, Mala Kamboj¹, Akhil Girdhar¹

¹Department of Oral and Maxillofacial Pathology and Microbiology, Post Graduate Institute of Dental Sciences, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak, Haryana, India.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

|August 8, 2023

概括

血管新生是口腔平坦菌长期存在的关键. 本综述强调了血管内皮生长因子 (VEGF) 和口腔平坦的进展中的其他因素,表明了潜在的治疗点.

科学领域:

口腔病理学口腔病理学
免疫皮肤学免疫皮肤学
血管新生研究研究

背景情况:

口腔平坦 (OLP) 是一种具有免疫源的慢性炎症性疾病.
血管新生在OLP病变和慢性病变中的作用尚不清楚.
了解OLP中的血管生成对于开发有效治疗方法至关重要.

研究的目的:

审查有关血管新生在口腔平坦菌中的作用的现有文献.
为了确定参与OLP进展的关键血管性因素.
探索计量学治疗在OLP管理中的潜力.

主要方法:

在主要数据库 (PubMed,Scopus,EMBASE等) 中进行全面的文献搜索. ) 的情况.
包括使用免疫组织化学来评估OLP中的血管生成的原始研究文章.
使用修改后的纽卡斯尔-太华规模进行偏差风险评估.

主要成果:

综合了29项研究,CD34是最常用的抗体.
升调的血管内皮生长因子 (VEGF) 表达是主要发现.
细胞间粘附分子-1 (ICAM-1),血管细胞粘附分子-1 (VCAM-1) 和血小板内皮细胞粘附分子-1 (PECAM-1) 被确定为关键的血管性因素.

结论:

血管新生是一个基本的机制,有助于OLP的持久性和慢性.
需要进一步研究更大的样本大小和标准化标准.
向血管生成可能为OLP提供新的治疗策略.

关键词:

血管新生是因为血管新生.慢性病慢性病慢性病慢性病免疫组织化学免疫组织化学在口腔中,有平坦的海.这是一个渐进的过程.

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