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Updated: Jul 19, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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Published on: May 14, 2021

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Uba7的冷-EM结构揭示了ISG15激活和E1-E2转移的分子基础

Mohammad Afsar1, GuanQun Liu2, Lijia Jia1

  • 1Department of Biochemistry & Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.

Nature communications
|August 8, 2023
PubMed
概括

结构洞察力揭示了Uba7如何激活和转移ISG15到UBE2L6,这对先天免疫至关重要. 这些发现揭示了ISG15结合的分子机制,影响抗病毒反应和细胞信号通路.

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