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Updated: Jul 19, 2025

Direct Measurement of KDM1A Target Engagement Using Chemoprobe-based Immunoassays
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Direct Measurement of KDM1A Target Engagement Using Chemoprobe-based Immunoassays

Published on: June 13, 2019

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在口腔状细胞癌中促进癌变:通过LEF1抑制KDM4A复合体介导的基因转录

Yiming Hou1, Wenqian Yu2,3,4, Gaoyi Wu5

  • 1Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, 250012, China.

Cell death & disease
|August 8, 2023
PubMed
概括

淋巴细胞增强剂结合因子1 (LEF1) 通过抑制LATS2表达促进口腔状细胞癌 (OSCC). 针对LEF1或KDM4A显示了OSCC早期诊断和治疗的潜力.

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