丸激素和男性膀癌之间的关系
Wei Tan1,2, Liang Gao2, Ye Yuan2
1Department of Urology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.
Scientific reports
|August 8, 2023
概括
这项研究发现,较高的血清总水平与男性膀癌 (BC) 发生之间存在显著的相关性. 其他因素如血红蛋白,高血压,糖尿病和吸烟也与BC风险有关.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 膀癌 (BC) 的发病率在男性中明显高于女性.
- 这种差异表明雄激素,如丸激素在BC发育中的潜在作用.
研究的目的:
- 调查雄激素水平与膀癌之间的关联.
- 确定在男性占主导地位的人群中导致膀癌的潜在风险因素.
主要方法:
- 一项病例对照研究包括147名初级膀癌患者和154名对照患者.
- 统计分析包括曼-惠特尼U测试,Chi-square测试和单变量/多变量逻辑回归.
- 分析了血清总水平和其他临床因素与BC的相关性.
主要成果:
- 多变量分析显示,血清总水平与膀癌之间存在显著的相关性 (OR 1.002,P=0.017).
- 血红蛋白水平 (OR 0.981,P=0.002),高血压 (OR 2.780,P<0.001),糖尿病 (OR 3.313,P=0.008) 和吸烟 (OR 1.938,P=0.009) 也与BC相关.
- 单变量分析显示了这些因素的相似显著差异.
结论:
- 血清总水平与膀癌的发生有显著的相关性.
- 包括血红蛋白,高血压,糖尿病和吸烟在内的因素也独立地与膀癌风险有关.
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