基于CT的放射基因组学框架用于COVID-19使用ACE2成像表示
Tian Xia1, Xiaohang Fu2, Michael Fulham2,3
1School of Computer Science, Faculty of Engineering, The University of Sydney, Sydney, NSW, 2006, Australia. Tian.Xia@sydney.edu.au.
Journal of digital imaging
|August 8, 2023
概括
这项研究引入了ACE2-RGF,这是一种新的放射基因组学方法,使用CT成像特征来评估血管激素转化酶2 (ACE2) 的表达. ACE2-RGF有助于COVID-19的诊断和严重疾病的识别.
科学领域:
- 放射学 放射学是一门学科.
- 基因组学就是基因组学.
- 人工智能的人工智能
背景情况:
- 冠状病毒疾病2019 (COVID-19) 病原发生涉及血管素转化酶2 (ACE2) 的表达.
- 对ACE2的基因表达概况是侵入性的和昂贵的.
- 医学成像,就像CT一样,为评估异常提供了一个非侵入性的替代方案.
研究的目的:
- 开发一个放射基因组学框架 (ACE2-RGF) 来推导与ACE2表达相关的成像特征.
- 在COVID-19患者中利用ACE2-RGF作为ACE2表达的替代生物标志物.
- 评估ACE2-RGF在分类COVID-19和识别严重疾病方面的表现.
主要方法:
- 使用来自肺腺癌 (LUAD) 患者的ACE2表达数据开发了一个放射基因组学框架.
- 使用ElasticNet和LASSO识别了与ACE2表达相关的图像特征.
- 来自ACE2-RGF的ACE2-RGF被测试了其分类COVID-19和预测严重疾病的能力.
主要成果:
- 与传统方法相比,ACE2-RGF发现了与传统方法相比独特的图像特征.
- 在将COVID-19从正常受试者中分类时,ACE2-RGF实现了0.92的AUC.
- 在确定患有严重疾病的患者时,ACE2-RGF显示AUC为0.85.
结论:
- ACE2-RGF作为ACE2表达的可行的替代生物标志物.
- 这种放射基因组学方法为自动化COVID-19分析提供了潜力.
- 这些发现支持进一步研究基于成像的传染病生物标志物.
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