来自绿色玄米叶的新型的潜在抗高血压活性
Pattaneeya Prangthip1, Watanalai Panbangred2, Onrapak Reamtong3
1Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. Pattaneeya.pra@mahidol.ac.th.
BMC complementary medicine and therapies
|August 8, 2023
概括
来自绿色玄米叶的新可以显示出抗高血压的潜力. 一种改善了高血压大鼠的脂质配置和肝功能,这表明对心血管健康有好处.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 营养保健品 营养保健品
背景情况:
- 高血压是一个重要的全球健康风险因素.
- 新型抗高血压提供潜在的治疗替代品.
- 绿色玄米叶被探索为生物活性化合物的来源.
研究的目的:
- 发现和描述从绿色玄米叶中获得的新型抗高血压.
- 评估两种分离的的体内抗高血压和相关作用.
主要方法:
- 从绿色白中分离出两个生物活性:1 (ACE抑制) 和2 (抗氧化活性).
- 雄性Wistar大鼠被诱导使用NG-nitro-l-arginine甲基 (L-NAME) 来确定高血压 (HT).
- 为了进行比较,HT大鼠接受了 1, 2,或抗高血压药物 (HTD) 的治疗.
主要成果:
- 在HT大鼠中,L-NAME诱导体重下降,氧化代谢物 (酸盐和酸盐) 减少,葡萄糖和肝酶升高.
- 与HT老鼠相比,HTD治疗恶化了脂质样本 (增加了LDL和LDL/HDL比率).
- 1对HT大鼠的脂质状况,肝功能,抗氧化剂状况,酸盐/酸盐水平和血管新生素II水平表现出有益影响.
- 二没有显示显著的有益影响.
结论:
- 来自绿色玄米叶的具有抗高血压潜力.
- 1表现出有前途的治疗效果,特别是与血管扩张和代谢改善有关.
- 对玄米衍生的进一步研究可能会导致管理高血压的新策略.
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