后COVID-19疾病和与性别和性别的关联
Kenneth Mangion1,2, Andrew J Morrow3,4, Robert Sykes3,4
1School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK. kenneth.mangion@glasgow.ac.uk.
BMC cardiovascular disorders
|August 8, 2023
概括
妇女在COVID-19后体验了更糟糕的健康结果,包括心肌炎症的更高率和较差的患者报告措施. 尽管如此,与男性相比,她们的心血管住院率较低.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 医疗成像医学成像
背景情况:
- 后COVID-19综合征经常与女性有关,但潜在的病理生理学仍然不清楚.
- 现有研究表明,在COVID-19感染后,心肌炎炎症和患者报告的健康结果可能存在基于性别的差异.
研究的目的:
- 为了前性地调查COVID-19幸存者在康复期间多器官损伤的时间过程.
- 探索后COVID-19条件的呈现和恢复的基于性别的差异.
主要方法:
- 一项前性研究,涉及临床信息,血液生物标志物和患者报告的结局措施,这些数据是在入学时和出院28-60天后收集的.
- 随访时进行心脏磁共振 (CMR) 和胸部计算机断层扫描 (CT) 成像.
- 评估严重不良事件,包括死亡和再住院,在平均随访450天期间.
主要成果:
- 与男性相比,女性 (43%) 在索引录取期间表现出较低的峰值C反应蛋白和费里丁水平.
- 女性更有可能在CMR上显示肌肉心脏炎症的证据 (54%对33%).
- 女性报告疾病感知更差,焦虑和抑郁更高,预测的最大氧气利用率更低,但心血管住院率较低 (0%vs8%).
结论:
- 妇女在COVID-19后的患者报告结果较差,无论是在最初的入院期间还是在28-60天的随访期间.
- 尽管主观结果较差,但与男性相比,女性心血管住院的发生率较低.
- 该研究强调了COVID-19后恢复轨迹和炎症标志物的显著性别差异.
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