主要肺化清细胞癌与声带状细胞癌:一个病例报告与系统审查
Zhuo Li1, Weihua Li1, Liyan Xue2,3
1Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17, Panjiayuan Nanli, Chaoyang District, Beijing, 100021, China.
Diagnostic pathology
|August 8, 2023
概括
化透明细胞癌 (HCCC) 是一种罕见的肺癌,可以被误诊为状细胞癌 (SCC). 下一代测序有助于诊断肺性HCCC,特别是在之前有SCC史的情况下.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 遗传学 是一个遗传学.
背景情况:
- 初级肺化清细胞癌 (HCCC) 是一种罕见的,低度的唾液腺类恶性瘤.
- 此前在医学文献中仅报告了23例肺性HCCC病例.
研究的目的:
- 要呈现一种与声带状细胞癌 (SCC) 同时发生的初级肺HCCC病例.
- 调查下一代测序 (NGS) 对肺部HCCC的诊断实用性.
- 在大型数据库中分析肺性HCCC的发病率和特征.
主要方法:
- 一名患有肺HCCC和声带SCC同时存在的患者接受了放射治疗和随后的手术切除.
- 切除瘤的组织病理学检查.
- 针对性RNA测序用于识别基因融合 (EWSR1-ATF1).
- 对肺癌恶性瘤的监测,流行病学和最终结果 (SEER) 数据库 (2000-2019) 的分析.
- 对肺部HCCC病例与EWSR1融合的文献综述.
主要成果:
- 该研究在肺部HCCC病例中发现了EWSR1-ATF1融合.
- 对SEER数据库的分析表明,头癌 (ACC和HNSCC) 是常见的并发性恶性瘤.
- 对EWSR1融合的24例肺HCCC病例的审查显示,淋巴结转移和复发的发病率较低.
- 肺部HCCC可能被误诊为SCC,需要仔细的差异诊断.
结论:
- 呈现清晰细胞的肺瘤需要谨慎的诊断.
- NGS是诊断肺部HCCC的一个有价值的工具,特别是在有SCC史的患者中.
- 准确的诊断至关重要,因为肺部HCCC和SCC之间的治疗有所不同.
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