静脉注射德克斯梅德托米丁对在拉皮镜胆囊切除术期间对肺上皮质的血液动力反应的影响
Rashna Shakya1,2, Shyam Krishna Maharjan1
1Department of Anaesthesiology, Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.
Asian journal of anesthesiology
|August 8, 2023
概括
在腹腔镜胆囊切除术期间,静脉注射德克斯梅德托米丁 (0.5微克/千克) 并没有显著减弱肺皮管的血液动力学反应. 这项研究发现,接收德克斯梅托米丁或正常盐水的组之间血压或心率没有差异.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 德克斯梅德托米丁是一种强大的α-2激动剂,用于减轻手术期间的压力反应.
- 腹腔镜胆囊切除术涉及肺上皮质,这可能导致显著的血液动力学变化.
研究的目的:
- 评估静脉注射德克斯梅德托米丁 (0.5毫克克/公斤) 在减弱对肺皮的血液动力学反应的疗效.
- 在全身麻醉下进行腹腔镜胆囊切除术时评估德克斯梅德托米丁对血液动力学的影响.
主要方法:
- 一项双盲研究将60名患者 (ASA-PS I类,18-60岁) 随机分为两组.
- 组A接受了正常的盐水,而组B在麻醉诱导前静脉注射了德克斯梅德托米丁 (0.5微克/千克).
- 血液动力学参数 (心率,血压) 被监测在肺经皮之后.
主要成果:
- 在肺皮后的德克斯梅德托米丁和正常盐水组之间没有观察到血液动力学参数的统计学上显著差异 (P > 0.05).
结论:
- 德克斯梅德托米丁在0.5mcg/kg的诱导前给药并没有有效地减轻对肺皮的血液动力学反应.
- 研究结果表明,在这种情况下,这种剂量的德克斯梅德米丁不足以控制肺皮质诱导的血液动力应激.
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