相关实验视频
Updated: Jul 19, 2025
09:36
Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
27.1K
儿童不同年龄段的BMI与年轻成人心脏代谢障碍相关
Yi Qian1, Yawei Kong2, Naijun Wan1
1Department of Pediatrics, Beijing Jishuitan Hospital, Beijing, China.
Obesity (Silver Spring, Md.)
|August 9, 2023
概括
儿童肥胖与成人心脏代谢障碍从小就有关. 这项研究表明,儿童时期的体重指数 (BMI) 可以预测风险,支持早期肥胖查.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 儿童肥胖是一个日益严重的公共卫生问题.
- 儿童时期的肥胖是已知的成人心脏代谢疾病的风险因素.
- 这种关联变得显著的确切年龄尚未确定.
研究的目的:
- 确定儿童肥胖 (通过体重指数z-score测量) 与成人心脏代谢障碍相关的年龄.
- 在不同年龄组中确定与儿童肥胖相关的特定心脏代谢风险因素.
- 为儿童肥胖早期查和干预的指导方针提供信息.
主要方法:
- 分析了811名儿童体重指数 (BMI) 测量和成人心脏代谢数据的参与者队列.
- 成年人的心脏代谢结果包括血压,脂质概况,禁食血糖,禁食胰岛素和氨酸转移酶.
- 经过对共变量进行调整的统计分析,以评估儿童BMIz分数与各种儿童年龄组 (6-9, 10-12, 13-15, 16-18岁) 成人心脏代谢障碍之间的关联.
主要成果:
- 儿童BMIz分数与所有研究儿童年龄组 (6-18岁) 的整体心脏代谢障碍和成年期高血压风险增加显著相关.
- 与低高密度脂蛋白胆固醇和胰岛素抵抗的关联从10-12岁及以上的年龄观察到.
- 高水平的甘油三和氨酸转移酶在13-15岁及以上的年龄段显示出显著的关联,而总胆固醇,LDL胆固醇或禁食血糖没有发现关联.
结论:
- 儿童肥胖和成人心脏代谢障碍之间的联系从幼儿时期就很明显.
- 这些发现强调了儿童肥胖普遍查的重要性,从幼年开始.
- 早期识别和管理儿童肥胖症可能会减轻未来心脏代谢疾病的风险.
相关概念视频
01:24Obesity
534
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
534
01:30Coronary Artery Disease I: Introduction
20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20
01:15Diabetes: Symptoms, Diagnosis, and Complications
590
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
590
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
16
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
16
01:19Overview of Carbohydrate Metabolism
1.2K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.2K
01:27Psychoneuroimmunology: Cardiovascular Disease
51
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
51