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Updated: Jul 19, 2025

Three-dimensional Cell Culture Model for Measuring the Effects of Interstitial Fluid Flow on Tumor Cell Invasion
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组织流动性的变化预测了vivo中的瘤侵略性.

Frank Sauer1, Steffen Grosser1,2, Mehrgan Shahryari3

  • 1Soft Matter Physics Division, Peter-Debye-Institute for Soft Matter Physics, 04103, Leipzig, Germany.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|August 9, 2023
PubMed
概括

癌症的进展涉及组织流体化,而不仅仅是硬. 新的基于物理学的模型和磁共振弹性图 (MRE) 揭示了预测瘤攻击性和转移的机械性质.

关键词:
癌症 癌症 癌症 癌症 癌症在体内磁共振弹性学 in vivo磁共振弹性学.医学成像医学成像组织流动性 组织流动性瘤机械学的机制

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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