在帕金森病中使用电生理学对认知网络的任务相关重组
May Bar-On1,2, Shaked Baharav1,2,3, Zoya Katzir1,4
1Laboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
概括
帕金森病 (PD) 患者由于大脑网络活动的改变而表现出认知缺陷,包括大脑波功率和连接性的变化. 这些发现突显了PD的网络水平功能障碍,并可能为未来的治疗,如深度大脑刺激提供信息.
科学领域:
- 神经科学是一个神经科学.
- 认知神经学 认知神经学
- 生物医学工程 生物医学工程
背景情况:
- 在帕金森病 (PD) 中,认知缺陷很常见.
- 这些认知障碍背后的精确电生理机制尚不清楚.
- 了解神经网络的改变对于PD研究至关重要.
研究的目的:
- 通过使用电脑电图 (EEG) 来研究PD患者在认知任务期间的神经网络的改变.
- 确定与PD认知缺陷相关的特定电生理学标记.
- 探索大脑网络连接在PD相关认知功能障碍中的作用.
主要方法:
- 90名参与者 (60名PD患者,30名对照人) 在GO/NOGO任务期间接受了EEG记录.
- 对16个感兴趣的区域应用源本地化来分析功率密度和连接性.
- 图形理论分析 (集群系数,程度,全球效率) 评估了网络组织.
主要成果:
- 患有PD的患者在GO/NOGO任务上表现较差.
- 患有PD的患者表现出更高的三角形和三角形频段功率,以及更低的α和β频段功率.
- 与对照组相比,在PD患者中观察到网络连接的增加和更高的集群系数.
结论:
- 患PD的认知缺陷与大脑网络的显著改变有关.
- 这些变化包括频段的功率密度变化和网络连接性增加.
- 这些发现表明,通过网络层面的变化来告知适应性深度大脑刺激的潜力.
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