在24个月以下的儿童患者中,沃里康纳的血度和剂量
Silke E Gastine1, Kerstin K Rauwolf2, Stephanie Pieper2
1Institute of Pharmaceutical and Medical Chemistry - Department of Clinical Pharmacy, Westphalian Wilhelms University Münster, Münster, Germany.
在24个月以下的儿童中,沃里康纳 (VCZ) 的剂量尚未得到充分确立. 这项研究没有发现增加的毒性,但主要显示了亚治疗性暴露,强调了在这个年轻人群中需要进一步的药理动力学研究.
科学领域:
- 药理学 药理学是指药理学的学科.
- 儿科医学 儿科医学
- 传染性疾病 传染性疾病
背景情况:
- 沃里康纳 (VCZ) 是一种重要的抗真菌药物,已批准用于24个月及以上的儿童.
- 关于24个月以下婴儿的VCZ剂量和暴露的数据有限.
- 这项研究解决了在这个脆弱的儿科群体中关于VCZ使用的信息稀缺的问题.
研究的目的:
- 为了评估voriconazole (VCZ) 在24个月以下的免疫受损儿童的安全性和有效性.
- 评估这个年龄段的VCZ最低度和耐受性.
- 为了确定VCZ剂量,暴露和不良事件之间的潜在相关性.
主要方法:
- 在17名年龄在3至24个月以下的儿童中,对50次沃里康纳治疗发作进行了回顾性分析.
- 用于预防或经验治疗的VCZ,口服或静脉注射.
- 监测了低度和肝功能参数;记录了不良事件.
主要成果:
- 大多数患者 (57.9%) 呈现亚治疗性VCZ最低度 (<1 mg/L).
- 只有34.2%的样本达到推的目标范围 (1-6 mg/L).
- 没有观察到肝功能显著变化,仅有6%的发作因不良事件而停止治疗.
结论:
- 沃里康纳 (VCZ) 在24个月以下的儿童中似乎具有有利的安全性.
- 当前的实证剂量策略往往导致这个年龄组的亚治疗性暴露.
- 进一步的药理动力学研究对于优化婴儿和幼儿的VCZ剂量至关重要.
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