纤维细胞生长因子23与妊娠期糖尿病的发展有关
Carl-Friedrich Hocher1,2, Xin Chen1,3, Jiao Zuo1,3
1Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/ Pneumology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.
Diabetes/metabolism research and reviews
|August 9, 2023
概括
在母亲中,较高的完整纤维细胞生长因子23 (iFGF23) 水平与妊娠糖尿病 (GDM) 有关. 在这项德国出生队列研究中,胎儿iFGF23与GDM无关.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 纤维细胞生长因子23 (FGF23) 以其在骨和矿物代谢中的作用而闻名.
- 新兴研究表明,FGF23可能会影响2型糖尿病的发病因子.
- FGF23对妊娠糖尿病 (GDM) 的具体影响尚不清楚.
研究的目的:
- 为了研究母体和胎儿完整的FGF23 (iFGF23) 和切割的FGF23 (cFGF23) 和GDM之间的关联.
- 为了比较德国出生队列的母亲和新生儿的IFGF23和cFGF23水平.
主要方法:
- 在柏林出生队列中,分析了来自826对母婴对的母亲和带血样本.
- 使用ELISA试验量化iFGF23和cFGF23.
- 多变量回归分析以确定与GDM的独立关联.
主要成果:
- 与没有GDM的母亲相比,患有GDM的母亲表现出明显更高的母体iFGF23度 (19.73对13.23ppg/ml,p < 0.0001).
- 在GDM和非GDM组之间没有观察到母亲cFGF23度的显著差异.
- 在调整混因素后,母亲的iFGF23独立地与GDM相关,但仅在使用针对完整FGF23.23的特定测试时.
- 在GDM和非GDM组之间的带血样本中,没有发现iFGF23或cFGF23的差异.
结论:
- 母亲iFGF23,但不是胎儿iFGF23或cFGF23,在德国出生队列中与GDM独立相关.
- 这些发现突出了母亲FGF23在GDM病理生理学中的潜在作用.
- 对完整的FGF23的测试特异性对于检测这种关联至关重要.
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