红细胞中每日血红蛋白氧化节律的机制和生理功能
Andrew D Beale1, Edward A Hayter2, Priya Crosby1
1MRC Laboratory of Molecular Biology, Cambridge, UK.
The EMBO journal
|August 9, 2023
概括
红血细胞 (RBC) 呈现出日常的血红蛋白氧化节奏,独立于核细胞的昼夜钟. 这些红细胞节律与体温相关,这表明它们在温度调节中的作用.
科学领域:
- 生理学 生理学 生理学
- 生物化学 生物化学
- 时间生物学 时间生物学
背景情况:
- 细胞昼夜节律对于生理组织和人类健康至关重要.
- 红细胞 (RBC) 是最丰富的细胞,具有昼夜节律,但它们的功能仍然不清楚.
- 了解红细胞昼夜生物学对于理解系统生理调节至关重要.
研究的目的:
- 研究红细胞 (RBC) 中昼夜节律的生理功能.
- 开发一种用于测量红血球中的血红蛋白 (Hb) 氧化状态的新型试验.
- 探索红细胞昼夜节律与体温调节之间的关系.
主要方法:
- 开发了一种新型的生物化学试验,利用氧化回归敏感的共价连接来测量SDS介导溶解期间的Hb氧化状态.
- 在小鼠和人类红细胞中观察到Hb氧化 (体外和体内) 的每日节奏.
- 评估了影响核细胞昼夜节律的突变对红细胞节律的影响,并将Hb氧化与核心体温相关联.
主要成果:
- 从小鼠和人类的红细胞中鉴定出血红蛋白氧化状态的每日节律.
- 证明RBC昼夜节律是独立于核细胞中昼夜节律的.
- 发现红血球甲血球 (metHb) 水平与核心体温之间存在相关性,最低温度与最高的metHb相吻合.
- 通过酸增加metHb水平,通过氧化 (NO) 信号在小鼠的核心体温下降.
结论:
- 红细胞在血红蛋白氧化过程中表现出内在的昼夜节律.
- 这些红细胞昼夜节律与核心体温的调节有关.
- 红细胞昼夜节律可能在生理温度调节中发挥重要作用,独立于中央昼夜时钟.
相关概念视频
Oxygen Transport in the Blood
2.8K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
2.8K
Hemoglobin
3.7K
Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
3.7K
Redox Reactions
41
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
41
Factors Affecting Erythropoiesis
3.3K
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
3.3K
Erythropoiesis
4.4K
Red blood cells (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
4.4K
Factors Affecting Respiration
5.3K
Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:
5.3K


