抗体与药物合体在乳腺癌中的毒性概况:实际考虑
Andrea D'Arienzo1, Annarita Verrazzo1,2, Martina Pagliuca2,3
1Department of Clinical Medicine and Surgery, University of Naples "Federico II", Via Sergio Pansini 5, Naples 80131, Italy.
EClinicalMedicine
|August 9, 2023
概括
抗体-药物合物 (ADC) 提供向癌症治疗,但需要监测中性质减退和心脏问题等副作用. 本综述详细介绍了如何管理这些毒性,以有效治疗乳腺癌.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗体-药物结合物 (ADC) 是一种先进的抗瘤剂,可以将细胞毒药物输送到瘤中.
- 虽然ADCs通常耐受良好,但可能会导致可预测的不良反应,需要谨慎监测.
研究的目的:
- 审查与乳腺癌治疗中使用的ADCs相关的毒性现有证据.
- 为ADC相关不良事件的监测协议和管理策略提供指导.
主要方法:
- 对已批准和正在研究的乳腺癌晚期ADC进行文献综述.
- 概述常见的ADC毒性的机制,预防和管理.
主要成果:
- 常见的毒性包括中性质减退,恶心,吐,脱发,腹,左心室功能障碍和ILD/肺炎.
- 了解毒性机制是有效管理的关键.
结论:
- 积极的监测和及时干预对于管理ADC诱导的毒性至关重要.
- 有效的管理策略可以防止过早停止治疗或减少剂量,优化患者的治疗结果.
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