博森坦用于COVID-19感染的高风险门诊患者:一个随机,双盲,安慰剂控制的随机试验
Shaahin Shahbazi1, Zahra Vahdat Shariatpanahi2, Erfan Shahbazi3
1Department of Internal Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Iran.
博森坦是一种内甲素受体阻断剂,在高风险的COVID-19患者中显著减少了住院治疗和血栓栓塞事件. 早期使用博森坦治疗可能会改善结果并防止疾病的进展.
科学领域:
- 心血管医学 心血管医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- COVID-19与内皮细胞激活和损伤有关,可能是由于内皮蛋白-1的过分分泌.
- 内皮功能障碍在COVID-19的严重程度和并发症中发挥着作用.
研究的目的:
- 为了评估博森坦的疗效,一个内甲素受体阻塞剂,在预防高风险的COVID-19门诊患者的疾病进展.
- 评估博森坦对COVID-19患者住院,死亡和血栓塞栓事件的影响.
主要方法:
- 一个随机的,安慰剂控制的试验,涉及高风险的COVID-19门诊患者.
- 患者在标准治疗的同时,接受博森坦 (62.5毫克每天两次) 或安慰剂30天.
- 主要结局是住院或15天内死亡;次要结局包括血栓塞栓事件和30天死亡率.
主要成果:
- 博森坦显著降低了15天内住院或死亡的主要结果 (2.3%对11.5%,P=0.006).
- 血栓塞栓事件在博森坦组明显较低 (1%对8.7%,P=0.008).
- 接受博森坦的患者在没有入院的日数显著增加 (P=0.004).
结论:
- 早期服用博森坦可能是高风险COVID-19门诊患者的有益治疗策略.
- 博森坦显示出预防疾病进展和减少COVID-19中血栓栓塞并发症的潜力.
- 这些发现表明,内甲素受体阻断是治疗严重COVID-19的一个有希望的方法.
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