可溶性CD93类似学菌素的域隔离剂HMGB1用于改善炎症性疾病
Shang-En Huang1, Cheng-Hsiang Kuo2, Si-Yu Shiao3,4
1Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Theranostics
|August 9, 2023
概括
可溶性CD93 (sCD93) 与高流动性组盒1蛋白 (HMGB1) 结合,减少炎症. 这项研究揭示了sCD93的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- CD93是一种糖蛋白,在炎症期间可以作为可溶性CD93 (sCD93) 脱落.
- sCD93增强了细胞亡的清除,是潜在的炎症性疾病生物标志物.
- sCD93的直接抗炎作用需要进一步研究.
研究的目的:
- 为了调查sCD93是否封存高流动性组盒1蛋白 (HMGB1).
- 探索sCD93通过HMGB1结合的潜在抗炎性质.
- 评估sCD93在炎症条件下的治疗潜力.
主要方法:
- 使用哺乳动物表达系统制备的可溶性复合人体CD93 (rCD93).
- 通过共免疫沉和结合试验评估了rCD93-HMGB1的相互作用.
- 在炎症,血管疾病和骨质疏松症的细胞和动物模型中评估了rCD93的影响.
主要成果:
- 可溶性rCD93,特别是它的D1域,与HMGB1结合并阻止HMGB1受体相互作用.
- 可溶性rCD93抑制了巨细胞和VSMC中的HMGB1诱导的炎症反应,减少了AAA.
- 可溶性rCD93通过阻碍HMGB1信号来缓解RANKL诱导的骨质结晶和骨质疏松症.
结论:
- 含有D1域的可溶性rCD93对炎症性疾病具有治疗潜力.
- sCD93通过隔离HMGB1并防止其受体相互作用,起到抗炎作用.
- 这种机制突显出一种新的治疗策略,用于炎症状况.
关键词:
CD93 CD93 CD93 CD93 CD93 CD93 CD93 CD93 CD93 CD93 CD93 CD93腹部大动脉动脉瘤 腹部大动脉动脉瘤高流动性组第1框 (HMGB1) 蛋白质这是一种炎症炎症炎症炎症.骨质疏松症是一种骨质疏松症.更多相关视频
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