生命之光:免疫评分免疫检查点,免疫疗法反应的预测指标
Assia Hijazi1,2,3, Carlotta Antoniotti4, Chiara Cremolini4
1INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.
Oncoimmunology
|August 9, 2023
概括
一种新的生物标志物Immunoscore-IC准确地预测了非小细胞肺癌和结直肠癌患者对免疫检查点抑制剂的反应. 这种分析量化免疫细胞密度和距离,优于PD-L1标记物指导免疫疗法决策.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物开发 生物标志物开发
背景情况:
- 免疫检查点 (IC) 阻塞疗法已经推进了癌症治疗,但对非小细胞肺癌 (NSCLC) 需要预测生物标志物.
- 目前用于预测NSCLC中IC治疗反应的方法不足.
- 了解瘤免疫微环境对于有效的癌症免疫疗法至关重要.
研究的目的:
- 识别和验证一种新的生物标志物Immunoscore-IC,用于预测NSCLC和结直肠癌 (CRC) 中对免疫检查点抑制剂 (ICI) 的反应.
- 为了评估Immunoscore-IC在ICI治疗中分层患者的疗效.
- 将Immunoscore-IC的预测值与PD-L1标记器进行比较.
主要方法:
- 免疫评分-IC测定量化了PD-L1+和CD8+细胞的密度以及瘤微环境中的它们之间的距离.
- 该试验在接受ICI的NSCLC患者中得到了验证.
- 在AtezoTRIBE试验中,在转移性CRC患者中评估了Immunoscore-IC的预测价值.
主要成果:
- 免疫评分-IC有效地将NSCLC患者分为ICI的响应者和不响应者.
- 与NSCLC中的PD-L1标志物相比,Immunoscore-IC显示出更高的预测价值.
- 在转移性CRC中,Immunoscore-IC确定了具有熟练不匹配修复 (pMMR) 的患者,他们受益于检查点抑制剂.
结论:
- 免疫评分-IC是一种强大的预测生物标志物,用于在NSCLC和CRC中对抗PD-1/PD-L1免疫疗法反应.
- 这种生物标志物有可能成为一种通用工具,用于跨多种癌症类型的患者分层.
- 免疫评分-IC帮助临床医生做出有关结合癌症治疗策略的明智决策.
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