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克服异种CAR-T细胞疗法的瓶的策略

Zixin Lv^1,2, Feifei Luo^2,3, Yiwei Chu^1,2

¹Department of Immunology, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Frontiers in immunology

|August 9, 2023

概括

全基化化学抗原受体 (CAR) -T细胞疗法在制造上比自身的CAR-T细胞具有优势. 克服移植与宿主疾病和宿主排斥对于其广泛的临床应用至关重要.

科学领域:

免疫治疗是一种免疫疗法.
细胞疗法细胞疗法
在瘤学瘤学.

背景情况:

自体仿真抗原受体 (CAR) -T细胞疗法显示出希望,但面临制造方面的挑战,包括长时间的生产时间和可变的功效.
这些局限性阻碍了广泛的临床应用和及时的患者治疗.

研究的目的:

审查当前的战略,以克服在全源CAR-T细胞疗法的关键挑战.
突出全源CAR-T细胞治疗作为"现成"产品的潜力.

主要方法:

综述关于全源CAR-T细胞疗法的现有文献.
对减轻移植对宿主疾病 (GvHD) 和宿主排斥的方法的分析.
综合有关制造工艺和临床结果的数据.

主要成果:

全基性CAR-T细胞疗法提供了一个简化的制造工艺和"现成"产品的潜力.
仍然存在重大障碍,包括严重的GvHD和宿主介导的全排斥.
目前的研究重点是工程解决方案,以解决这些安全问题.

结论:

解决GvHD和宿主排斥是成功临床转化全原CAR-T细胞疗法的关键.
开发强大的全基CAR-T细胞产品将扩大各种癌症的治疗可用性.

关键词:

T细胞子集是T细胞的子集.一种全基性CAR-T细胞.基因编辑技术基因编辑技术非基因编辑技术的技术.多能干细胞是多能干细胞.

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