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免疫检查点蛋白质,细胞因子和微生物群对宫衰竭和早产患者的影响

Seri Jeong¹, Won Kyong Cho², Yeonhwa Jo²

¹Department of Laboratory Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.

Frontiers in immunology

|August 9, 2023

概括

宫微生物组和炎症因素,如化学基因CC动机连接体2可以预测早产. 细菌Moraxella osloensis和高化学基因CC动机连接体2水平在宫内样本中是关键预测因素.

科学领域:

生殖免疫学生殖免疫学
微生物组研究的研究.
孕产妇和胎儿的医学

背景情况:

宫缺陷和早产与微环境因素有关,如微生物诱导的炎症和免疫检查点蛋白质.
在宫微环境中微生物组和免疫因素之间的精确相互作用仍然不完全理解.
了解这些因素对于治疗宫缺陷和预防早产至关重要.

研究的目的:

探索和比较微生物组,炎症性细胞因子和免疫检查点蛋白之间的相互作用,在患有宫衰竭和早产的患者中.
在子宫微环境中识别预测早产的因素.
为了评估早产预测因子组合的性能.

主要方法:

从怀孕妇女,包括患有宫衰竭和对照妇女的宫内和宫外囊样本收集.
利用枪元基因组测序来分析宫微生物组.
在宫样本中测量了34种免疫检查点蛋白和炎症性细胞因子.

主要成果:

免疫检查点蛋白在宫内和宫外样本中成功测量.
在宫衰竭和早产时,确定了不同的宫微环境.
宫内内Moraxella osloensis的存在和升高的化学基因CC动机连接体2水平与早产有显著的关联 (分别OR=14.785,P=0.037;OR=40.049,P=0.005).

结论:

在宫微生物组,免疫检查点蛋白和细胞因子之间建立了关系.
鉴定了Moraxella osloensis和化学因子CC动机连接体2作为早产的关键预测因子.
这些因素的组合在预测早产 (AUC=0.846) 方面表现出色.

关键词:

宫性衰竭是什么意思宫的子宫可以细胞因子细胞因子免疫检查点蛋白质的免疫检查点蛋白质这是一种炎症炎症炎症炎症.微生物组是一个微生物组.过早分娩过早分娩是什么

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