系统性炎症反应指数与急性心肌梗塞患者的短期死亡率之间的非线性关系:MIMIC-IV的回顾性研究
Yufei Wang1,2, Hua Chen1,2
1Graduate School, Inner Mongolia Medical University, Hohhot City, China.
Frontiers in cardiovascular medicine
|August 9, 2023
概括
系统性炎症反应指数 (SIRI) 是急性心肌梗塞 (AMI) 患者死亡率和重症监护室停留的重要预测指标. 较高的SIRI水平与短期死亡风险的增加有关.
科学领域:
- 关键护理医学 关键护理医学
- 心血管研究的心血管研究.
- 炎症标志物是一种炎症标志物.
背景情况:
- 急性心肌梗塞 (AMI) 是危急疾病的主要原因之一.
- 预测性生物标志物对在重症监护室 (ICU) 患有AMI的患者的短期死亡率至关重要.
- 系统性炎症反应指数 (SIRI) 是一种潜在的预后工具.
研究的目的:
- 评估SIRI在预测AMI的ICU患者所有原因的短期死亡率方面的有效性.
- 调查SIRI水平与死亡率和逗留时间之间的关联.
主要方法:
- 使用MIMIC-IV数据库进行回顾性队列研究.
- 包括在ICU诊断出AMI的4291名患者.
- 对SIRI四分位数和十二分位数进行了多变量回归和卡普兰-梅尔分析.
主要成果:
- SIRI四分位数独立地与增加的30日和90日死亡率有关.
- 在ln-SIRI和90天死亡率之间观察到一个曲线关系,有值效应.
- 较高的SIRI四分位数 (Q2,Q4) 与更长的ICU停留时间有关,而Q3与更短的住院停留时间有关.
结论:
- 在关键性AMI患者中,SIRI是30日和90天死亡的独立风险因素.
- 与NLR相比,SIRI可能是短期死亡率的优越预测因素.
- 在AMI患者中,SIRI既影响了死亡率,也影响了在ICU停留的时间.
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