在持续的姿势感知头中,前庭视觉体感和空间认知皮层区域之间的功能连接的变化:视觉刺激前后的静止状态fMRI研究
Chihiro Yagi1, Yuka Morita1, Tatsuya Yamagishi1
1Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Frontiers in neurology
|August 9, 2023
概括
持续的姿势感知性头 (PPPD) 涉及大脑连接的改变,特别是与视觉刺激. 这项研究发现PPPD患者的功能连接性存在差异,这解释了视觉恶化和症状延长.
科学领域:
- 神经科学是一个神经科学.
- 静脉管疾病 静脉管疾病
- 功能神经成像 功能神经成像
背景情况:
- 持续的姿势感知性头 (PPPD) 是一种慢性前体综合征.
- 视觉刺激是PPPD的关键加剧因素,需要对潜在的神经机制进行调查.
- 假设功能连接 (FC) 变化,而不是简单的激活,是PPPD视觉恶化的基础.
研究的目的:
- 通过检查功能连接 (FC) 变化来研究PPPD的神经基础.
- 在PPPD患者和健康对照中比较视觉刺激前后的FC模式.
- 确定与PPPD视觉恶化相关的大脑网络中的特定变化.
主要方法:
- 使用休息状态fMRI (rs-fMRI) 和基于任务的fMRI.
- 11名PPPD患者和11名健康对照 (HC) 参与了这项研究.
- 在视觉刺激任务之前和之后获得fMRI扫描.
主要成果:
- 预刺激:PPPD与HC中的下垂体视觉和上层体感视觉FC.
- 在PPPD中,视觉空间-空间认知FC升高,不像HC中那样增加后刺激.
- 后刺激:在PPPD中增加视觉空间认知和视觉前额 FC;在视觉任务期间大脑激活没有群体差异.
结论:
- 在PPPD网络中,前庭输入可能未得到充分利用.
- 视觉空间空间认知和体感视觉FC的改变有助于PPPD的视觉恶化.
- 视觉-认知/前额FC后刺激增加可能解释PPPD的长期症状和焦虑.
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