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Updated: Jul 19, 2025

A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells
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HIB/SPOP通过调节RNA聚合酶II组件的稳定性来抑制Ci/Gli介导的瘤发生

Yuxue Gao1, Zhaoliang Shan1, Chunhua Jian1

  • 1State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Jiangsu Key Laboratory of Molecular Medicine, Model Animal Research Center, School of Medicine, Nanjing University, Nanjing 210061, China.

iScience
|August 9, 2023
PubMed
概括

过度表达Ci/Gli和击倒Drosophila中的蜂会导致类似瘤的眼睛生长. HIB/SPOP通过控制蛋白质稳定性来抑制这种作用,揭示了瘤发生的双重作用.

关键词:
细胞生物学 细胞生物学遗传学 是一个遗传学.模型生物模型生物.

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