瘤衍生的共价有机框架纳米酶用于向的化疗-光热联合治疗
Shengnan Zhou1, Tian Tian2, Tao Meng1
1Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, P.R. China.
iScience
|August 9, 2023
概括
这项研究引入了用于肝癌治疗的生物仿真纳米酶. 它将共价有机框架 (COF) 与金纳米颗粒和西斯相结合,提供有针对性的化学光热治疗,并改善生物相容性.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 联有机框架 (COF) 在抗癌疗法中表现有前途,但具有较差的生物相容性和较低的目标特异性.
- 开发用于癌症治疗的有效药物输送系统仍然是一个重大挑战.
研究的目的:
- 创建一个仿生多功能COF纳米酶用于肝癌的协同化学光热疗法.
- 在临床应用中克服传统COFs的局限性.
主要方法:
- 制造一个共价有机框架 (COF) 纳米酶 (TPE-s COF) 封装金纳米粒子 (Au NPs) 和.
- 与HepG2细胞共同培养,使细胞膜与纳米酶融合,形成一个非活化形式 (M@TPE的COF-Au@Cisplatin).
- 利用激光照射触发治疗剂的释放,从而产生结合化学-光热效应.
主要成果:
- 开发的纳米酶证明了与HepG2细胞膜的有效融合,导致了无活化,内细胞化形式.
- 激光照射成功触发了纳米酶裂变,释放了TPE的COF-Au和西斯.
- 释放的成分有效地对肝癌治疗产生光热和药物治疗作用.
结论:
- 这项工作介绍了一种新的生物仿真纳米酶策略,用于向性肝癌治疗.
- 开发的瘤衍生光纳米酶为高效,协同的化学-光热联合治疗提供了有前途的方法.
- 这种方法提高了生物相容性和目标特异性,为临床翻译铺平了道路.
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