在7989名可卡因使用障碍患者中,多重物质成模式
Brendan Stiltner1,2, Robert H Pietrzak1,3, Daniel S Tylee1,2
1Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA.
iScience
|August 9, 2023
概括
在可卡因使用障碍 (CoUD) 中,多物质成 (PSA) 呈现出三种不同的模式. 在CoUD中高PSA与人格障碍,情绪障碍,PTSD和性病的风险增加有关.
科学领域:
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
- 临床心理学 临床心理学
背景情况:
- 可卡因使用障碍 (CoUD) 经常与其他物质使用障碍同时发生,这种情况被称为多物质成 (PSA).
- 了解COUD患者中PSA的模式对于有效的治疗和研究至关重要.
- 之前的研究并没有完全描述基于PSA严重性的COUD内的不同子组.
研究的目的:
- 在被诊断患有可卡因使用障碍 (CoUD) 的大量个体中识别和表征明显的多物质成 (PSA) 模式.
- 检查与CoUD中不同PSA亚组相关的人口和临床相关性,特别是并发症.
主要方法:
- 隐性类分析 (LCA) 用于7989名参与者的数据集,他们一生都被诊断为CoUD的DSM-5.
- 参与者被分为三个PSA小组:低水平 (17%),中等水平 (38%) 和高水平 (45%).
- 在这些子组中分析了人口统计学变量 (年龄,性别,种族-种族,教育,收入) 和临床并发症.
主要成果:
- 在COUD患者中发现了三种不同的PSA亚组 (低,中,高).
- 虽然根据PSA水平的人口分布有显著差异 (p < 0.001),但教育和收入没有差异 (p > 0.05).
- 与低PSA小组相比,高PSA小组的反社会人格障碍, agoraphobia,混合双相情节,PTSD,抗抑郁药物使用和性病的几率明显更高,即使在控制人口因素之后.
结论:
- 这些发现突显了可卡因使用障碍中多重物质成的异质性.
- PSA 严重程度是与 CoUD 中广泛的精神病并发症和健康问题相关的关键因素.
- 对 CoUD 的临床和研究方法应该包括对 PSA 严重程度和相关并发症的评估,以便全面了解和量身定制的干预措施.
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